Pakistan-born comedian Kumail Nanjiani and grad student Emily Gardner fall in love but struggle as their cultures clash. When Emily contracts a mysterious illness, Kumail finds himself forced to face her feisty parents, his family's expectations, and his true feelings.

The Three Amigos, a silent screen comedy act, arrive in a remote Mexican hamlet for what they think is a lucrative personal appearance, only to discover that they are expected to save the village from a terrorizing gang of bandits.