When eighty-five-year-old Miriam Caravasios slips through the ice to her death, Delphine, a frightened and insecure young woman who adored her grandmother, falls under scrutiny when it is revealed that Miriam's will cut off her children, leaving her almost everything and emboldening her to find the truth.

Three grown Southern sisters have ten marriages between them-and more loom on the horizon-when Ginger, the eldest, wonders if shes the only one who hasnt inherited what their family calls "the Grandma Gene": the tendency to like the casualness of courtship better than the intimacy of marriage. Could it be that her two sisters are fated to serially marry, just like their seven-times wed grandmother, Mrs. Lillian Irene Harper Winslow Goldstein Carey...

A series of unexplained deaths in foreign hospitals sends Jennifer Hernandez, an idealistic UCLA medical student, on a desperate search for answers about her grandmother's sudden death. With the discovery of other unexplained deaths followed by hasty cremations, Jennifer reaches out to her mentor, New York City medical examiner Dr. Laurie Montgomery, who has her own deep connection to Jennifer's grandmother.