A deadly, mysterious epidemic is sweeping the country, and young kidnap victim Callie is one of the few who survived infection, only to be sacrificed by her captors at a secret lab working with antimatter; her older brother Kai is desperate to find out what happened to her--his best hope lies with Shay, the girl who last saw Callie alive, and together they will seek answers, even if it means evading soldiers and crossing the quarantine zone.

When a child goes missing from the Orphan House in the town of Stone-in-the-Glen, the mayor suggests the kindly Ogress is responsible, but the orphans do not believe that and try to make their deluded neighbors see the real villain among them.