Once the nation's foremost criminologist and the ex-head of NYPD forensics, quadriplegic Lincoln Rhyme abandons his forced retirement and joins forces with rookie cop Amelia Sachs to track down a vicious serial killer.

A woman awakes in the morning to find that someone has picked her apartment's supposedly impregnable door lock and rearranged personal items, even sitting beside her while she slept. The intrusion, the police learn, is a message to the entire city of carnage to come. Lincoln Rhyme and Amelia Sachs are brought in to investigate and soon learn that the sociopathic intruder, who calls himself 'the Locksmith,' can break through any lock or security system...