A band of misfit kids searches for buried treasure in a subterranean cavern. Here they cross the path of Mama Fratelli and her outlaw brood. The kids befriend Fratelli's hideously deformed (but soft-hearted) son, who comes to their rescue.

Treasure hunters Nathan Drake and Victor Sullivan race to find the lost fortune of Ferdinand Magellan, and hopefully also Nathan's long-lost brother, before Santiago Moncada, who believes that he is the fortune's rightful heir.